PREPARATION OF SILICA PARTICLES

摘要

The present invention provides a cost-efficient method for producing particles having a SiO2 containing surface wherein said method comprises a) providing an aqueous reaction composition comprising i) core particles, ii) an added base, iii) a silicate salt, and iv) a pH modulator wherein the pH value of the reaction composition is above the gelation pH value; b) agitating said reaction composition, wherein the pH modulator decreases the pH value of the reaction composition over time and wherein due to said decrease of the pH value of the reaction composition SiO2 is deposited onto the core particles, whereby particles are formed which have a diameter of 30 μm or less; and c) obtaining the particles. Furthermore, silica particles having high nucleic acid binding properties are provided.

主权项

1. A method for producing particles having a SiO2 containing surface comprising:
a) providing an aqueous reaction composition comprising
i) core particles,ii) an added base,iii) a silicate salt, andiv) a pH modulatorwherein the pH value of the reaction composition is above the gelation pH value of the silica salt; b) agitating said reaction composition, wherein the pH modulator is an organic compound that reacts in the alkaline milieu of the reaction composition, thereby decreasing the pH value of the reaction composition over time and wherein due to said decrease of the pH value of the reaction composition, SiO2 is deposited onto the core particles, whereby particles are formed which have a diameter of 30 μm or less; and c) obtaining the particles.