PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF

摘要

Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.

主权项

1. A chimeric antigen receptor-effector cell switch comprising:
a. a peptidic antigen that binds a chimeric antigen receptor on an effector cell; and b. a targeting moiety that binds a cell surface molecule on a target cell.