| 发明名称 |
PROCESS FOR THE PREPARATION OF CABAZITAXEL AND ITS INTERMEDIATES |
| 摘要 |
The present invention relates to a novel process for preparation of cabazitaxel (I) starting from 10-Deacetyl baccatin or derivative that involves methylation of 7, 10 —OH groups. Also provided is a novel process using chiral bis-lactam linker for the synthesis of cabazitaxel. |
| 申请公布号 |
US2015307468(A1) |
申请公布日期 |
2015.10.29 |
| 申请号 |
US201314441726 |
申请日期 |
2013.10.31 |
| 申请人 |
INTAS PHARMACEUTICALS LIMITED |
发明人 |
Lourdusamy Mettilda;Radu Ioan Iosif;Saxena Rahul Chandrashayi;Patel Raghvendra Jayantibhai;Shah Sandeep Bachubhai |
| 分类号 |
C07D305/14 |
主分类号 |
C07D305/14 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process to prepare cabazitaxel (I) comprising a step of:
reacting a compound of formula II in which X represents H or side chain of formula (III) Z represents a hydroxy protecting group, R1 is C(O)OC(CH3)3 with methyl trifluoromethansulfonate to get compound of formula (IV) |
| 地址 |
Ahmedabad IN |
