ALPINIA SPP. EXTRACTS FOR TREATING IRRITABLE BOWEL SYNDROME

摘要

Disclosed herein is the use of an extract from Alpinia spp. for the preparation of a medicament for the treatment of irritable bowel syndrome (IBS). The extract is prepared by extracting fresh and/or dried fruits of Alpinia spp. plant with a solvent such as a supercritical fluid, water, 10-95% (v/v) ethanol, acetone, ethyl acetate or n-hexane, to obtain an extract suitable for the preparation of IBS medicaments. In some embodiments, active compounds with anti-abnormal defecation activity and/or analgesia effect are isolated from the water extract of Alpinia spp.; these compounds are therefore potential lead compounds for use as medicaments for treating IBS.

主权项

1. An extract of Alpinia spp. for manufacturing a medicament for treating irritable bowel syndrome (IBS) comprising teucrenone or isalpinin; and at least one active compound selected from the group consisting of oxyphyllenodiol A, 6-α-hydroxy-7-epi-α-cyperone, 7-epi-teucrenone, and tectochrysin.