| 发明名称 |
ONCOLYTIC ADENOVIRUS ARMED WITH THERAPEUTIC GENES |
| 摘要 |
The present invention involves compositions and methods for treating cancer using a mutant adenovirus comprising a polynucleotide encoding a therapeutic polypeptide that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming cells with a wild type retinoblastoma pathway. |
| 申请公布号 |
US2015306160(A1) |
申请公布日期 |
2015.10.29 |
| 申请号 |
US201514703876 |
申请日期 |
2015.05.04 |
| 申请人 |
Board of Regents, The University of Texas System |
发明人 |
FUEYO Juan;GOMEZ-MANZANO Candelaria;YUNG W. K. Alfred;CONRAD Charles A.;LANG, JR. Frederick F. |
| 分类号 |
A61K35/761;A61K38/50;C12N15/86;A61K38/17;A61K48/00;A61K31/513;A61K45/06;A61K38/18 |
主分类号 |
A61K35/761 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating a brain tumor in a patient comprising:
a) identifying a patient having a brain tumor; and b) contacting the tumor with an oncolytic adenovirus that encodes a therapeutic gene and an E1A polypeptide that cannot bind Rb. |
| 地址 |
Austin TX US |
