| 发明名称 |
METHODS OF DETECTING REVERSE TRIIODOTHYRONINE BY MASS SPECTROMETRY |
| 摘要 |
Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample. |
| 申请公布号 |
US2015308991(A1) |
申请公布日期 |
2015.10.29 |
| 申请号 |
US201414533900 |
申请日期 |
2014.11.05 |
| 申请人 |
Quest Diagnostics Investments, Inc. |
发明人 |
BANKS J. Fred;CHOU Peter P.;MATT Noriya M. |
| 分类号 |
G01N30/72;H01J49/04;G01N33/78;H01J49/00 |
主分类号 |
G01N30/72 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for determining the amount of reverse triiodothyronine (rT3) in a sample by tandem mass spectrometry, said method comprising:
a. subjecting the rT3 from the sample to liquid chromatography; b. ionizing rT3 from the sample and an internal standard to generate at least one rT3 ion and at least one internal standard ion detectable by tandem mass spectrometry; c. determining the amount of said at least one rT3 ion and the amount of said at least one internal standard ion by tandem mass spectrometry; and d. determining the amount of rT3 in the sample, comprising comparing the amount of said at least one rT3 ion and the amount of said at least one internal standard ion. |
| 地址 |
San Clemente CA US |
