COAGULATION FACTOR VII POLYPEPTIDES

摘要

The present invention relates to modified coagulation Factor VII (Factor VII) polypeptides having coagulant activity as well as polynucleotide constructs encoding such polypeptides, vectors and host cells comprising and expressing such polynucleotides, pharmaceutical compositions, uses and methods of treatment.

主权项

1. A Factor VII(a) polypeptide comprising two or more substitutions relative to the amino acid sequence of human Factor VII (SEQ ID NO:1),
wherein at least one of the substitutions is where T293 has been replaced by Lys (K), Tyr (Y), Arg (R) or Phe (F); where Q176 has been replaced by Lys (K), Arg (R), Asn (N); and/or Q286 has been replaced by Asn (N) and wherein at least one of the substitutions is where M298 has been replaced by Gln (Q), Lys (K), Arg (R), Asn (N), Gly (G), Pro (P), Ala (A), Val (V), Leu (L), Ile (I), Phe (F), Trp (W), Tyr (Y), Asp (D), Glu (E), His (H), Cys (C), Ser (S), or Thr (T).