| 摘要 |
The present invention provides methods of using compounds of formula I: or compositions thereof for the inhibition of FLT3, and the treatment of FLT3-mediated disorders'. Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful for treating a variety of diseases, disorders or conditions, associated with regulation of signaling pathways implicating FL T3 kinases. Such diseases, disorders, or conditions include those described herein. Compounds provided by this invention are also useful for the study of FL T3 enzymes in biological and pathological phenomena; the study of intracellular signal transduction pathways occurring in bodily tissues; and the comparative evaluation of new FL T3 inhibitors or other regulators of kinases, signaling pathways, and cytokine levels in vitro or in vivo. |
