METHOD FOR PREDICTING GENE CLUSTER INCLUDING SECONDARY METABOLISM-RELATED GENES, PREDICTION PROGRAM, AND PREDICTION DEVICE

摘要

This invention provides a method for predicting a gene cluster including secondary metabolism-related genes with high accuracy, independent of information concerning core genes. Such method comprises: a step of identifying a region the gene arrangement of which is conserved in nucleotide sequence information of another genome as a gene cluster on the basis of the results of homology search conducted with the use of nucleotide sequence information of at least a pair of genomes; and a step of determining whether or not the gene cluster of interest includes secondary metabolism-related gems on the basis of the proportion of synteny-like regions within the gene cluster identified by the above step.

主权项

1. A method for predicting a gene cluster including secondary metabolism-related genes comprising:
a step of subjecting genes included in nucleotide sequence information of at least a pair of genomes to homology search mutually to identify homologous gene combinations in the nucleotide sequence information of the genomes and orthologous gene combinations in the homologous gene combinations; a step of identifying a region of the gene arrangement of which is conserved in the nucleotide sequence information of other genomes as a gene cluster on the basis of the results of homology search; and a step of identifying a synteny-like region in the gene cluster identified in the previous step on the basis of the presence of orthologous genes determined as a result of homology search and evaluating whether or not the gene cluster includes secondary metabolism-related genes on the basis of the rate of the synteny-like region in the gene cluster.