USE OF MICRORNA 146-A IN THE DIAGNOSIS, TREATMENT AND PREVENTION OF PICORNAVIRUS INFECTION AND MICRORAN 146-A ANTAGONISTS

摘要

The present invention found that host miRNAs might be involved in Picornavirus pathogenesis through suppression of type I IFNs induction and could act as candidates for developing antiviral therapy. Thus, the invention suggests enterovirus-induced miR-146a facilitates viral pathogenesis by suppressing IFN production and provide a clue to develop the preventive and therapeutic strategies for enterovirus infections.