HEMOGLOBIN RECEPTOR AS NOVEL VACCINE FOR LEISHMANIASIS

摘要

The present invention in general relates Hemoglobin receptor or its part as a novel vaccine candidate against Leishmaniasis. Specifically, the present invention envisages HbR DNA for eliciting immune response in a mammal against Leishmaniasis. Additional aspect of the present invention is related to a vaccine composition for inducing immune response against Leishmaniasis in mammals. In a preferred aspect, the present invention relates to use of HbR-polypeptide as marker for diagnosis of Leishmania in kala-azar patients.

主权项

1. A HbR-DNA for inducing sterile protection against virulent Leishmania, wherein said DNA comprises nucleotide sequence selected from the group consisting of: a) nucleotide sequence as set forth in any one of SEQ ID NO: 1 (HbR-FL), SEQ ID NO: 2 (HbR-N) or fragments thereof; b) a nucleotide sequence that encodes polypeptide having amino acid sequence as set forth in SEQ ID NO: 3.