| 发明名称 |
NOVEL ORAL FORMS OF A PHOSPHONIC ACID DERIVATIVE |
| 摘要 |
Novel solution complexes of zoledronic acid are described which give rise to improved properties of zoledronic acid. The invention includes aqueous solution and molecular complexes of zoledronic acid with and optical isomers of asparagine, histidine, arginine and proline as well as pharmaceutical complexes containing them and methods of treatment using them. |
| 申请公布号 |
US2015306116(A1) |
申请公布日期 |
2015.10.29 |
| 申请号 |
US201514657184 |
申请日期 |
2015.03.13 |
| 申请人 |
THAR PHARMACEUTICALS, INC. |
发明人 |
HANNA Mazen;SHAN Ning;CHENEY Miranda;WEYNA David R. |
| 分类号 |
A61K31/675 |
主分类号 |
A61K31/675 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A solution complex of a bisphosphonic acid or bisphosphonate comprising a bisphosphonic acid or bisphosphonate with a coformer wherein the aqueous solubility of the bisphosphonic acid or bisphosphonate is improved over the bisphosphonic acid or bisphosphonate alone. |
| 地址 |
Pittsburgh PA US |
