发明名称 |
METHODS FOR REDUCING REMNANT CHOLESTEROL AND OTHER LIPOPROTEIN FRACTIONS BY ADMINISTERING AN INHIBITOR OF PROPROTEIN CONVERTASE SUBTILISIN KEXIN-9 (PCSK9) |
摘要 |
The present invention provides methods for reducing various lipoprotein fractions in the serum of patients. The methods of the invention include reducing serum remnant cholesterol, and/or the serum concentration of one or more LDL-C subfractions in a patient. The methods of the present invention comprise selecting a patient who exhibits elevated serum lipoproteins, and administering to the patient a pharmaceutical composition comprising a PCSK9 inhibitor. In certain embodiments, the PCSK9 inhibitor is an anti-PCSK9 antibody such as the exemplary antibody referred to herein as mAb316P. |
申请公布号 |
WO2014194168(A3) |
申请公布日期 |
2015.10.29 |
申请号 |
WO2014US40163 |
申请日期 |
2014.05.30 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
SWERGOLD, GARY;SASIELA, WILLIAM, J.;PORDY, ROBERT, C. |
分类号 |
A61K39/00;A61K39/395;A61P9/10;C07K16/40 |
主分类号 |
A61K39/00 |
代理机构 |
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