发明名称 |
SINGLE-CHAIN TRAIL-RECEPTOR AGONIST PROTEINS |
摘要 |
Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications. |
申请公布号 |
CA2946402(A1) |
申请公布日期 |
2015.10.29 |
申请号 |
CA20152946402 |
申请日期 |
2015.04.23 |
申请人 |
ABBVIE INC.;APOGENIX AG |
发明人 |
HILL, OLIVER;GIEFFERS, CHRISTIAN;THIEMANN, MEINOLF;BUCHANAN, FRITZ G.;PHILLIPS, DARREN C.;LAPPE, SUSAN E. |
分类号 |
C07K19/00;A61P25/28;A61P35/00;C07K14/52;C07K14/705;C12N5/10;C12N15/62 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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