| 发明名称 |
BIOMOLECULE DETECTION METHOD, BIOMOLECULE DETECTION DEVICE AND ANALYSIS DEVICE |
| 摘要 |
The present invention is intended to provide a method and a device for detecting a biomolecule with high sensitivity and high throughput over a wide dynamic range without requiring concentration adjustments of a sample in advance. The present invention specifically binds charge carriers to a detection target biomolecule, and detects the detection target biomolecule one by one by measuring a current change that occurs as the conjugate of the biomolecule and the charge carriers passes through a micropore. High-throughput detection of a biomolecule sample is possible with an array of detectors. |
| 申请公布号 |
US2015308977(A1) |
申请公布日期 |
2015.10.29 |
| 申请号 |
US201314418480 |
申请日期 |
2013.06.28 |
| 申请人 |
Hitachi High-Technologies Corporation |
发明人 |
Saito Toshiro;Imai Kenta;Imai Kyoko;Imai Kazumichi;Yanagi Itaru;Yanagawa Yoshimitsu;Ando Masahiko;Itabashi Naoshi |
| 分类号 |
G01N27/414;G01N33/543 |
主分类号 |
G01N27/414 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A biomolecule detection method comprising:
causing a reaction between a detection target biomolecule, a first charge carrier with a surface having a first antibody against the biomolecule, and a second charge carrier with a surface having a second antibody against the biomolecule to form a conjugate containing the first and second charge carriers; and detecting the conjugate by measuring an amount of charge on the charge carriers forming the conjugate with the biomolecule. |
| 地址 |
Tokyo JP |
