发明名称 |
CONTROLLING THE ACTIVITY OF GROWTH FACTORS, PARTICULARLY TGF-BETA, IN VIVO |
摘要 |
TGF-β growth factor and its latent complex are conjugated to magnetic micro- or nanoparticles and to magnetic micro- or nanodiscs. By exposing the resulting conjugates to magnetic fields, the TGF-β growth factor can be released from its latent complex in vivo, potentially making it useful in tissue engineering and regenerative medicine. And by exposing a conjugate of TGF-β growth factor and a magnetic particle to a sufficiently strong, radiofrequency magnetic field, the TGF-β growth factor can be denatured and thereby deactivated, potentially making it possible to avoid triggering tumorigenesis, atherosclerosis, fibrotic disease, and cancer. |
申请公布号 |
US2015306220(A1) |
申请公布日期 |
2015.10.29 |
申请号 |
US201414261586 |
申请日期 |
2014.04.25 |
申请人 |
University of Florida Research Foundation, Incorporated |
发明人 |
Monsalve Adam;Dobson Jon P. |
分类号 |
A61K41/00;A61K38/18;B01J19/08;A61K47/48 |
主分类号 |
A61K41/00 |
代理机构 |
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代理人 |
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主权项 |
1. A conjugate of TGF-β and a magnetizable particle. |
地址 |
Gainesville FL US |