VACCINE COMPOSITION FOR USE IN IMMUNO-COMPROMISED POPULATIONS

摘要

The invention relates to nasally-administered vaccine compositions effective against infection in immuno-compromised populations. One aspect of the invention is directed to the pediatric use of the vaccine of the invention including a vaccine effective in children against seasonal influenza virus strains. A further aspect of the invention is directed to subjects of all age groups when the composition is for pandemic use.

主权项

1. A method of immunizing an immune-compromised subject against influenza for reducing virus shedding comprising:
administering intranasally to an immuno-compromised subject a composition comprising:
i) one or more non-live influenza virus antigen(s) selected from the group consisting of whole inactivated virus, split virus, subunit influenza antigen, and recombinant antigens, andii) an adjuvant comprising:
one or more carboxylic acids,an aqueous medium, andone or more mono-glycerides.