PEPTIDIC ANTAGONISTS OF CLASS III SEMAPHORINS/NEUROPILINS COMPLEXES

摘要

The present invention concern a peptidic antagonist of class III semaphorins/neuropilins complexes comprising an amino acid sequence, which is derived from the transmembrane domain of a protein selected in the group consisting of neuropilin-1, neuropilin-2, plexin-A1, plexin-A2, plexin-A3, plexin-A4, Nr-CAM, L1-CAM, integrin Beta 1 and integrin beta 2, and including at least a GxxxG motif, eventually fused to an heterologous sequence; a nucleic acid encoding for said peptidic antagonist, a pharmaceutical composition comprising such a peptidic antagonist or a nucleic acid encoding thereof and uses thereof.

主权项

1. A peptidic antagonist of class III semaphorins/neuropilins complexes consisting of:
a transmembrane domain of a protein selected from the group consisting of neuropilin-1, neuropilin-2, plexin-A1, plexin-A2, plexin-A3, plexin-A4, Nr-CAM, L1-CAM, integrin beta 1 and integrin beta 2, wherein the transmembrane domain is optionally fused to a heterologous sequence, or an amino acid sequence of less than 50 amino acid long and more than 14 amino acid long having an identity of more than 80% with a transmembrane domain of a protein selected from the group consisting of neuropilin-1, neuropilin-2, plexin-A1, plexin-A2, plexin-A3, plexin-A4, Nr-CAM, L1-CAM, integrin beta 1 and integrin beta 2 and including at least one GxxxG motif, wherein the amino acid sequence of less than 50 amino acid long and more than 14 amino acid long retains the biological properties of the transmembrane domain and wherein the amino acid sequence of less than 50 amino acid long and more than 14 amino acid long is optionally fused to the heterologous sequence.