Glucagon/GLP-1 Agonists For The Treatment Of Obesity

摘要

This disclosure provides GLP-1/glue agon agonist peptides for the treatment of metabolic diseases, e.g., obesity.

主权项

1. An isolated peptide comprising the amino acid sequence:
HX2QGTFTSDX10SX12X13 LX15X16X17X18AX20X21FX23X24WLX27X28GX30; wherein X2 is G or S, X10 is Y or K, X12 is K, E, R, or S, X13 is K or Y, X15 is D or E. X16 is S or G, X17 is E, R, Q, or K, X18 is R, S, or A, X20 is R, K, or Q, X21 is D or E, X23 is V or I, X24 is A or Q, X27 is E or V, X28 is A or K, and X30 is G or R (SEQ ID NO:4).