ARTICLE WITH HOLLOW MICRONEEDLES AND METHOD OF MAKING

摘要

The present application provides articles (10) having a polymeric substrate (12) with a plurality of solid and/or hollow microneedles (20) extending therefrom. Each solid microneedle is formed by a molding process and the microneedle has body with first (30) and second cavities (40) extending therein. The hollow microneedles are formed by removing a portion of the polymeric material disposed between the first cavity and the second cavity. A method for determining the location of a microneedle in an article comprising solid microneedles is also provided. The method comprises directing electromagnetic radiation toward an article comprising a plurality of microneedles and imaging the article.

主权项

1. An article, comprising:
a substrate having first side and second side opposite the first side; wherein the first side comprises a first major surface that defines a base from which at least one microneedle extends;
wherein the at least one microneedle comprises a body, a tip and a first cavity extending into the body;
wherein the first cavity comprises an opening on the first side and a first terminus; wherein the second side comprises a second major surface comprising a second cavity that extends into the body of the at least one microneedle;
wherein the second cavity comprises a second opening on the second side, and a second terminus; wherein the first terminus is spaced apart from the second terminus; wherein a straight line passing through the substrate can enter the substrate at a first point in the second cavity and exit the substrate at a second point in the first cavity.