Trimeric HIV Fusion Inhibitors for Treating or Preventing HIV Infection

摘要

Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.

主权项

1. A method of inhibiting the fusion of a human immunodeficiency virus (HIV) to a target cell comprising:
administering a trimeric polypeptide pharmaceutical composition to the target cells, wherein the composition comprises a trimeric polypeptide, wherein the trimeric polypeptide comprises three polypeptide monomers, each polypeptide monomer consisting of a fusion peptide consisting of the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) of the transmembrane glycoprotein gp41 of HIV fused to a foldon trimerization motif, wherein the NHR is N28, and wherein the foldon trimerization motif sequence is fused to the C-terminus of the NHR; and inhibiting fusion of the virus to the cell.