STABILIZED MODIFIED RELEASE VITAMIN D FORMULATION AND METHOD OF ADMINISTRING SAME
摘要
A stabilized formulation for controlled release of a vitamin D compound is disclosed. The formulation comprises one or both of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 and a cellulosic compound. The stabilized formulations exhibit a stable dissolution profile following exposure to storage conditions and demonstrate improved pharmacokinetic parameters compared to unstabilized formulations.
申请公布号
SG11201507323P(A)
申请公布日期
2015.10.29
申请号
SG11201507323P
申请日期
2014.03.14
申请人
OPKO IRELAND GLOBAL HOLDINGS, LTD.
发明人
WHITE, JAY, A.;MELNICK, JOEL, Z.;AGUDOAWU, SAMMY, A.;TABASH, SAMIR, P.