ORAL PHARMACEUTICAL COMPOSITION FOR DRUGS WITH A HIGH-DOSAGE REGIMEN

摘要

The present invention relates to an oral pharmaceutical composition for drugs with a high dosage regimen, specifically, ion exchange resins and bulk-forming laxatives. Said composition comprises the combination of a liquid oily component and a texturizing agent, giving the composition good organoleptic properties that allow taking drugs with a high dosage regimen without the usual problems associated with their poor palatability. The invention also relates to a method for preparing said composition and to the use thereof for the treatment of various pathologies. Furthermore, the invention also relates to an adduct formed between a polyol and an ion exchange resin, to a method for preparing it, and to the use thereof to improve resin palatability.

主权项

1. A pharmaceutical composition for oral administration comprising:
a) an active ingredient with a high dosage regimen selected from the group consisting of an ion exchange resin for therapeutic use and a bulk-forming laxative, b) an oily component selected from the group consisting of a vegetable oil, a medium-chain triglyceride, and mixtures thereof; and c) a texturizing agent selected from the group consisting of a hydrogenated vegetable oil, a macrogolglyceride of fatty acids, and mixtures thereof, wherein the composition is semisolid and substantially free of water and sucrose.