发明名称 |
RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS |
摘要 |
Disclosed are messenger RNA molecules and related compositions incorporating a 4′-thio modification in the furanose ring of at least one nucleotide residue, and methods of using these mRNAs to produce an encoded therapeutic protein in vivo and to treat or prevent diseases or disorders. In certain embodiments, the 4′-thio modified mRNA provides for enhanced stability and/or reduced immunogenicity in in vivo therapies. |
申请公布号 |
SG11201507474Q(A) |
申请公布日期 |
2015.10.29 |
申请号 |
SG11201507474Q |
申请日期 |
2014.03.14 |
申请人 |
SHIRE HUMAN GENETIC THERAPIES, INC. |
发明人 |
DEROSA, FRANK;HEARTLEIN, MICHAEL |
分类号 |
C07H5/10;C12N15/11 |
主分类号 |
C07H5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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