发明名称 COMBINATION THERAPY OF AFUCOSYLATED CD20 ANTIBODY WITH ANTI-VEGF ANTIBODY
摘要 PROBLEM TO BE SOLVED: To provide an afucosylated anti-CD20 antibody used in combination therapy with an anti-VEGF antibody, for the treatment of a CD20 expressing cancer such as a B-Cell Non-Hodgkin's lymphoma (NHL), and provide the combination therapy.SOLUTION: The afucosylated anti-CD20 antibody is an afucosylated anti-CD20 antibody with an amount of fucose of 60% or less of the total amount of oligosaccharides (sugars) at Asn297, particularly a humanized B-Ly1 antibody. The anti-VEGF antibody is bevacizumab, a B20 series antibody or G6 series antibody.
申请公布号 JP2015187130(A) 申请公布日期 2015.10.29
申请号 JP20150102724 申请日期 2015.05.20
申请人 ROCHE GLYCART AG 发明人 FRANK HERTING;CHRISTIAN KLEIN
分类号 A61K39/395;A61K45/00;A61P35/00;A61P43/00 主分类号 A61K39/395
代理机构 代理人
主权项
地址