| 摘要 |
PROBLEM TO BE SOLVED: To provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the gastrointestinal tract.SOLUTION: Some embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other gastrointestinal lumen. A device 10 comprises a capsule 20 sized to be swallowed and pass through the intestinal tract. The capsule can include at least one guide tube 30, one or more tissue penetrating members 40 positioned in the guide tube, a delivery member 50, an actuating mechanism 60 and a release element 70. The release element degrades upon exposure to various conditions in the intestine so as to release and actuate the actuating mechanism. The invention is particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the gastrointestinal tract. |
