DUAL EMISSIVE METAL NANOPARTICLES AS RATIOMETRIC PH INDICATORS

摘要

In some aspects, the present disclosure provides a dual emissive pH response noble metal nanoparticle which produces a ratiometric fluorescence signal based upon changes in the pH. In another aspect, the noble metal nanoparticle may be used in bioimaging applications as well as to detect in vivo changes of pH.

主权项

1. A nanoparticle comprising a noble metal nanoparticle, wherein:
the noble metal nanoparticle is about 0.1 nm to about 5 nm in diameter; the noble metal nanoparticle comprises a mixture of metal atoms in the ground oxidation state and a charged oxidation state; and the surface of the noble metal nanoparticle is coated with a first pH-dependent ligand.