ANIMAL MODEL WITH A FILAGGRIN GENE PROMOTER

摘要

The present invention is based upon the generation of a nucleic acid construct which may be used to generate transgenic non-human animals. The construct exploits a filaggrin based promoter region which directs the expression of a reporter sequence operatively linked thereto. The present invention provides a nucleic acid, said nucleic acid encoding a filaggrin promoter element and a nucleic acid sequence operatively linked thereto.