发明名称 |
MODIFIED GLYCOPROTEIN, PROTEIN-CONJUGATE AND PROCESS FOR THE PREPARATION THEREOF |
摘要 |
The invention relates to a glycoprotein comprising an optionally fucosylated glycan according to formula (105) or (106), wherein Su(A)x is a modified sugar moiety comprising one or more functional groups A. Functional group A is independently selected from the group consisting of a thiol group, a halogen, a sulfonyloxy group, a halogenated acetamido group, a mercaptoacetamido group and a sulfonated hydroxyacetamido group. The invention also relates to a glycoprotein-conjugate wherein a glycoprotein according to the invention is conjugated to a molecule of interest. Said molecule of interest may for example be an active substance. The invention further relates to a process for the preparation of a modified glycoprotein, and to a method for the preparation of a glycoprotein-conjugate. The invention particularly relates to modified antibodies, antibody-conjugates, antibody-drug conjugates and methods for the preparation thereof. |
申请公布号 |
EP2935608(A1) |
申请公布日期 |
2015.10.28 |
申请号 |
EP20140790774 |
申请日期 |
2014.10.14 |
申请人 |
SYNAFFIX B.V. |
发明人 |
VAN DELFT, FLORIS LOUIS;VAN GEEL, REMON;WIJDEVEN, MARIA ANTONIA;VERKADE, JORGE MERIJN MATHIEU;HEESBEEN, RYAN |
分类号 |
C12P21/00;A61P35/00;C07K16/00 |
主分类号 |
C12P21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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