NOVEL TRH BINDING SITE IN HUMAN CNS

摘要

The invention relates to a novel thyrotropin releasing hormone (TRH) receptor subtype in human central nervous system (CNS) that is pharmacologically distinct from the TRH receptor subtype in human pituitary. The invention provides a means to understand how the central actions of TRH are mediated and to isolate and characterise the novel receptor, as well as methods applicable to research and development of diagnostic and therapeutic applications in human CNS disorders.