Methods of monitoring for adherence to aripiprazole therapy

摘要

Methods for helping to monitor subject adherence with a prescribed antipsychotic drug treatment regimen are disclosed.

主权项

1. A method for recommending a modification to an aripiprazole therapy, the method comprising:
identifying a subject who is prescribed aripiprazole therapy; determining a prescribed aripiprazole dose associated with the prescribed aripiprazole therapy; measuring a concentration of OPC3373 and a creatinine level in urine of the subject; normalizing the concentration of OPC3373 as a function of the creatinine level; identifying the subject as non-adherent to aripiprazole therapy if the normalized concentration of OPC3373 is less than a predetermined level, and as adherent to aripirazole therapy if the normalized concentration of OPC3373 is greater than the predetermined level; and recommending a modification to the prescribed aripiprazole dose if the subject is identified as non-adherent, wherein the modification comprises a discontinuation of the aripiprazole therapy or a replacement of the aripiprazole therapy with a new therapeutic regimen.