Vault compositions for immunization

摘要

Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity.

主权项

1. A vaccine comprising a pathogen immunogenic peptide or a pathogen immunogenic fragment or variant thereof incorporated within a vault-like particle, wherein the vault-like particle comprises MVP, and wherein administration of the vaccine to a subject in need thereof stimulates a cellular immune response.