| 主权项 |
1. A compound represented by the following general formula (1): wherein: W is selected from: 1) C1-C6 alkylene optionally substituted with a fluorine atom, 2) C2-C6 alkenylene, X is a single bond, Y is an oxygen atom, m is 1; n is 1; R1 is represented by formula (3) or formula (4): R3 is selected from: 1) —CONR7R8, 2) —OR9, 3) —NR9R10, 4) —N(R9)COR11, 5) —N(R9)SO2R12, 6) —SO2R15, 7) C1-C2 alkyl optionally substituted with a group(s) independently selected from —COR16 and —NR13R14, R4 is selected from: 1) a halogen atom, 2) cyano, 3) C1-C10 alkyl optionally substituted with a group(s) independently selected from hydroxycarbonyl, C1-C10 alkoxycarbonyl and aminocarbonyl, 4) C1-C10 haloalkyl, 5) C1-C10 alkoxy, R5 is selected from a hydrogen atom, a halogen atom, C1-C10 alkyl, C1-C10 haloalkyl and C1-C10 alkoxy; R7 is selected from: 1) hydrogen, 2) C1-C10 alkyl optionally substituted with a group(s) independently selected from amino and C1-C10 alkylamino, 3) C1-C10 hydroxyalkyl, 4) C1-C10 haloalkyl, 5) C1-C10 heteroalkyl, 6) C1-C10 heteroalkyl optionally substituted with a group(s) selected from a hydroxyl group, C1-C10 alkylamino and C2-C10 alkenyl, 7) aryl, 8) heteroaryl, 9) aryl C1-C10 alkyl, 10) a heterocycle optionally substituted with C1-C10 alkyl, 11) —(CH2)LCOR16 (wherein L represents an integer of 1 to 4), 12) C1-C10 alkoxy, 13) C2-C10 alkenyl and 14) —NR40R41; R40 and R41 are independently selected from hydrogen, C1-C10 alkyl and C1-C10 alkylcarbonyl, or R40 and R41 may be bonded to each other to form a ring selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl and morpholinyl, and the heterocycle is optionally substituted with C1-C10 alkyl; R8 is selected from hydrogen and C1-C10 alkyl optionally substituted with a halogen atom(s) and/or a hydroxyl group(s); R7 and R8 may be bonded to form a 4- to 7-membered heterocycle optionally containing an additional element(s) or group(s) independently selected from O, N, S, SO and SO2, and the heterocycle optionally contains carbonyl, and the heterocycle is optionally substituted with a substituent(s) independently selected from: 1) a halogen atom, 2) C1-C10 alkyl optionally having C1-C10 alkylamino as a substituent(s), 3) C1-C10 haloalkyl, 4) a hydroxyl group, 5) C1-C10 hydroxyalkyl, 6) C1-C10 alkoxy optionally substituted with a group(s) independently selected from a halogen atom, a hydroxyl group, amino and C1-C10 alkylamino, 7) aryl optionally substituted with a group(s) selected from a halogen atom, a hydroxyl group, amino and C1-C10 alkylamino, 8) C1-C10 heteroalkyl optionally substituted with a group(s) independently selected from a halogen atom, a hydroxyl group, amino and C1-C10 alkylamino, 9) a heterocycle optionally substituted with C1-C10 alkyl, 10) heteroaryl optionally substituted with C1-C10 alkyl, 11) heterocyclyl C1-C10 alkyl, 12) —COR16, 13) —NR19R20, 14) —SO2R21, 15) C1-C10 alkoxy-C1-C10 alkyl optionally having a hydroxyl group(s) as a substituent(s) and 16) C1-C10 hydroxyalkyloxy, wherein the hydrogen atom of the hydroxyl group is optionally replaced by C1-C10 hydroxyalkyl, and the heterocycle may further form a spiro ring together with a 4- to 6-membered heterocycle, and the bonded 4- to 6-membered heterocycle optionally contains O and N as ring-forming elements in addition to carbon atoms, and the carbon atom(s) may be oxidized to form carbonyl, and the 4- to 6-membered heterocycle is optionally further substituted with C1-C10 alkyl; R16 is selected from: 1) a hydroxyl group, 2) C1-C10 alkoxy, 3) NR17R18 and 4) C1-C10 alkyl optionally substituted with a substituent(s) selected from a halogen atom, a hydroxyl group, C1-C10 alkoxycarbonyl or C1-C10 alkylamino; R17 is selected from: 1) hydrogen, 2) C1-C10 alkyl optionally substituted with a group(s) selected from aryl, amino, C1-C10 alkylamino, C1-C10 alkylcarbonylamino and a hydroxyl group, 3) heteroaryl and 4) C1-C10 alkoxy; R18 is selected from hydrogen, C1-C10 alkyl and C1-C10 hydroxyalkyl; R17 and R18 may be bonded to each other to form a ring selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl and morpholinyl, and the ring is optionally substituted with a group(s) selected independently of each other from C1-C10 alkyl, a halogen atom and C1-C10 alkoxycarbonyl; R19 is selected from hydrogen, C1-C10 alkyl, C1-C10 haloalkyl, C1-C10 alkylcarbonyl, C1-C10 hydroxyalkyl, C1-C10 aminoalkyl, C1-C10 alkoxycarbonyl and C1-C10 heteroalkyl; R20 is selected from hydrogen and C1-C10 alkyl; R19 and R20 may be bonded to form a ring selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl and morpholinyl, and the ring is optionally substituted with a group(s) selected independently of each other from C1-C10 alkyl and a halogen atom; R21 is selected from: 1) C1-C10 alkyl optionally substituted with aryl, 2) amino, 3) C1-C10 alkylamino and 4) aryl optionally substituted with C1-C10 alkyl; R9 is selected from: 1) hydrogen, 2) C1-C10 alkyl optionally substituted with a group(s) independently selected from R23, 3) cycloalkyl optionally substituted with a halogen atom(s) or a hydroxyl group(s), 4) a heterocycle optionally substituted with a group(s) independently selected from C1-C10 alkyl, C1-C10 alkylcarbonyl, C1-C10 alkoxy, C1-C10 alkoxycarbonyl, amino and a halogen atom, 5) C1-C10 heteroalkyl optionally substituted with a group(s) independently selected from a halogen atom and a hydroxyl group, 6) heteroaryl optionally substituted with a group(s) selected from C1-C10 alkyl, C1-C10 alkylcarbonyl, C1-C10 alkoxycarbonyl and a halogen atom and 7) cycloalkenyl optionally substituted with a group(s) selected from C1-C10 alkoxy, C1-C10 alkylamino, amino, a hydroxyl group and a halogen atom, wherein the cycloalkenyl optionally contains a carbonyl group; R23 is independently selected from: 1) a halogen atom, 2) a hydroxyl group, 3) a C1-C10 alkylcarbonyloxy group, 4) —COR16, 5) amino, 6) C1-C10 alkylamino, 7) a heterocycle optionally substituted with a group(s) selected from C1-C10 alkyl, C1-C10 alkylcarbonyl, C1-C10 alkoxycarbonyl and a halogen atom and 8) cyano; R10 is selected from: 1) hydrogen and 2) C1-C10 alkyl optionally substituted with a group(s) selected from a halogen atom, a hydroxyl group and aryl; R9 and R10 may be bonded to form a 4- to 7-membered heterocycle optionally containing an additional element(s) or group(s) independently selected from N, O, S, SO, SO2, carbonyl and thiocarbonyl, and the heterocycle is optionally substituted with a substituent(s) independently selected from R24; R24 is independently selected from: 1) a halogen atom, 2) C1-C10 alkyl optionally substituted with a group(s) independently selected from C1-C10 alkylamino and C1-C10 alkylcarbonylamino, 3) C1-C10 haloalkyl, 4) a hydroxyl group, 5) C1-C10 hydroxyalkyl, 6) C1-C10 alkoxy optionally substituted with a group(s) independently selected from a halogen atom, a hydroxyl group, amino and C1-C10 alkylamino, 7) aryl optionally substituted with a group(s) independently selected from a halogen atom, a hydroxyl group, amino and C1-C10 alkylamino, 8) C1-C10 heteroalkyl optionally substituted with 1 to 2 groups independently selected from a halogen atom, a hydroxyl group, amino and C1-C10 alkylamino, 9) —COR16, and 10) —NR19R20; R11 is selected from: 1) C1-C10 alkyl optionally substituted with 1 to 3 substituents independently selected from:
i) a hydroxyl group,ii) —NR17R18,iii) a C1-C10 alkoxy group,iv) a halogen atom,v) C1-C10 alkoxycarbonyl, andvi) aminocarbonyl, 2) aryl or aryl C1-C10 alkyl, 3) cycloalkyl optionally substituted with a halogen atom(s), 4) a heterocycle optionally substituted with a group(s) selected from C1-C10 alkyl, 5) C1-C10 alkoxy, wherein the alkyl group is optionally substituted with a group(s) independently selected from C1-C10 alkylcarbonylamino, amino, C1-C10 alkylamino and a hydroxyl group, 6) amino, 7) C1-C10 alkylamino, wherein the alkyl group is optionally substituted with a group(s) independently selected from C1-C10 alkylcarbonylamino, amino, C1-C10 alkylamino, hydroxycarbonyl and a hydroxyl group and 8) C2-C10 alkenyl; R12 is selected from: 1) C1-C10 alkyl, 2) amino and 3) C1-C10 alkylamino, wherein the alkyl group is optionally substituted with a group(s) independently selected from amino, C1-C10 alkylamino and a hydroxyl group; R13 is selected from: 1) hydrogen, 2) C1-C10 alkyl, 3) C1-C10 alkylcarbonyl, wherein the alkyl is optionally substituted with a hydroxyl group(s), 4) C1-C10 alkoxycarbonyl, 5) aminocarbonyl, 6) C1-C10 alkylaminocarbonyl and 7) heterocyclic carbonyl optionally substituted with C1-C10 alkyl; R14 is selected from: 1) hydrogen and 2) C1-C10 alkyl optionally substituted with a group(s) independently selected from a halogen atom, a hydroxyl group, amino and C1-C10 alkylamino; R13 and R14 may be bonded to form a 4- to 7-membered heterocycle optionally containing an additional element(s) or group(s) independently selected from O, N, S, SO and SO2, and the heterocycle optionally contains carbonyl, and the heterocycle is optionally substituted with C1-C10 alkyl; R15 is selected from: 1) C1-C10 alkyl and 2) —NR35R36; R35 is selected from: 1) hydrogen, 2) C1-C10 alkyl optionally substituted with a group(s) independently selected from:
i) a halogen atom,ii) a hydroxyl group,iii) C1-C10 alkylcarbonylamino,iv) —COR16,v) amino,vi) C1-C10 alkylamino,vii) C1-C10 alkoxy optionally substituted with a halogen atom(s),viii) heteroaryl optionally substituted with a C1-C10 alkyl group(s) andix) a heterocycle, 3) aryl optionally substituted with a group(s) independently selected from a halogen atom, a hydroxyl group, amino and C1-C10 alkylamino, 4) cycloalkyl optionally substituted with a group(s) independently selected from a halogen atom and a hydroxyl group, 5) a heterocycle optionally substituted with a group(s) independently selected from C1-C10 alkyl, a halogen atom and aryl C1-C10 alkyl, 6) heteroaryl optionally substituted with C1-C10 alkyl and 7) C1-C10 alkylcarbonyl; R36 is selected from: 1) hydrogen and 2) C1-C10 alkyl optionally substituted with a group(s) independently selected from a halogen atom, a hydroxyl group and aryl; R35 and R36 may be bonded to each other to form a ring selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl and morpholinyl, and the ring is optionally substituted with a group(s) selected independently of each other from C1-C10 alkyl and a halogen atom; R25 is selected from: 1) C1-C10 heteroalkyl optionally substituted with a hydroxyl group(s), and 2) C1-C10 alkyl optionally substituted with a hydroxyl group(s), R2 is selected from: 1) cyclohexyl, and 2) aryl optionally substituted with a group(s) independently selected from R44, R44 is selected from: 1) a halogen atom, 2) cyano, 3) C1-C10 alkyl optionally substituted with a group(s) independently selected from:
i) a hydroxyl group,ii) —OR26,iii) cyano,iv) aryloxy optionally substituted with a group(s) independently selected from a halogen atom, C1-C10 alkyl optionally substituted with a halogen atom(s) or C1-C10 alkoxy optionally substituted with a halogen atom(s), 4) C1-C10 haloalkyl, 5) cycloalkyl optionally substituted with a group(s) independently selected from a halogen atom and C1-C10 haloalkyl, 6) C1-C10 alkoxy optionally substituted with a halogen atom(s) or a C2-C6 alkenyl group(s), 7) —COR30, 8) C1-C10 heteroalkyl optionally substituted with a halogen atom(s), 9) aryl optionally substituted with a substituent(s) independently selected from:
i) C1-C10 alkyl,ii) aryl, 10) heteroaryl optionally substituted with a C1-C10 alkyl group(s), 11) —SO2R43, 12) C1-C10 alkylthio optionally substituted with a halogen atom(s), 13) —Si(R43)3 and 14) —SF5; R43 represents a C1-C10 alkyl group; R26 is aryl, or C1-C10 alkyl optionally substituted with a halogen atom(s); R30 is selected from a hydroxyl group, C1-C10 alkoxy and —NR31R32; R31 and R32 are independently selected from: 1) hydrogen, 2) C1-C10 alkyl optionally substituted with aryl and 3) aryl; R31 and R32 may be bonded to form a ring selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl and morpholinyl, and the ring is optionally substituted with a group(s) selected independently of each other from C1-C10 alkyl, a halogen atom and C1-C10 alkoxycarbonyl; and R33 and R34 are hydrogen, or a pharmacologically acceptable salt thereof. |
