发明名称 |
METHOD OF DIFFERENTIAL DIAGNOSTICS OF AUTOIMMUNE LIVER DISEASES |
摘要 |
FIELD: medicine.SUBSTANCE: invention is intended for differential diagnostics of various nosological forms of autoimmune liver diseases (AILD). To carry out differential diagnostics of autoimmune liver diseases clinical-and-laboratory, morphological and immunomorphologcal tests with immunhistochemical determination of bcl-2 in liver tissue are performed. Comparative analysis of content of bcl-2 positive cells is carried out and the level of percent content of bcl-2 is determined. Differential diagnostics is carried out between primary biliary cirrhosis if value is 66%-100% and cross syndrome - autoimmune hepatitis/primary biliary cirrhosis - lower than 66%; between autoimmune hepatitis - 33%-66% and primary biliary cirrhosis - 66%-100%; between autoimmune hepatitis 33%-66% and chronic viral hepatitis C - 0%-33%.EFFECT: application of invention makes it possible to increase reliability of differential diagnostics of cross syndromes of autoimmune liver diseases, with further optimisation of therapy, depending on stated diagnosis.1 dwg, 1 tbl, 3 ex |
申请公布号 |
RU2566723(C2) |
申请公布日期 |
2015.10.27 |
申请号 |
RU20140111578 |
申请日期 |
2014.03.25 |
申请人 |
FEDERAL'NOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE "NAUCHNO-ISSLEDOVATEL'SKIJ INSTITUT DETSKIKH INFEKTSIJ FEDERAL'NOGO MEDIKO-BIOLOGICHESKOGO AGENTSTVA";GOSUDARSTVENNOE BJUDZHETNOE OBRAZOVATEL'NOE UCHREZHDENIE VYSSHEGO PROFESSIONAL'NOGO OBRAZOVANIJA "SEVERO-ZAPADNYJ GOSUDARSTVENNYJ MEDITSINSKIJ UNIVERSITET IM. I.I. MECHNIKOVA MINISTERSTVA ZDRAVOOKHRANENIJA ROSSIJSKOJ FEDERATSII" |
发明人 |
RAJKHEL'SON KARINA LEONIDOVNA;KAREEV VADIM EVGEN'EVICH;MARCHENKO NATAL'JA VALER'EVNA;PAL'GOVA LJUDMILA KONSTANTINOVNA;LOBZIN JURIJ VLADIMIROVICH;BARANOVSKIJ ANDREJ JUR'EVICH |
分类号 |
G01N33/53 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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地址 |
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