Antibodies to MUC16 and methods of use thereof

摘要

The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to a polypeptide, or antigenic portion thereof, wherein the polypeptide is selected from a) MUC16 ectodomain polypeptide, b) MUC16 cytoplasmic domain polypeptide, and c) MUC16 extracellular domain polypeptide that contains a cysteine loop polypeptide. The invention's antibodies and compositions containing them are useful in diagnostic and therapeutic applications for diseases in which MUC16 is overexpressed, such as cancer.

主权项

1. An isolated antibody, or an antigen-binding fragment thereof, that specifically binds to a MUC16 polypeptide or to an antigenic portion thereof, wherein the MUC16 polypeptide is
TLDRSSVLVDGYSPNRNE (SEQ ID NO:02), wherein the antibody comprises a variable heavy (“VH”) chain encoded by SEQ ID NO:06 and a variable light (“VL”) chain encoded by SEQ ID NO:07.