发明名称 |
3-(5-methyl-2-oxo-l, 3-dioxol-4-yl) methyloxy-2-trans-[(4-chloro phenyl) cyclohexyl][1,4]naphthaquinone-atovaquone prodrug |
摘要 |
The present invention relates to atovaquone prodrug compound of formula (I). Accordingly, present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4-chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallization to provide Atovaquone prodrug compound of formula (I) in high yields, purity, and suitable for large-scale manufacture. |
申请公布号 |
US9169232(B2) |
申请公布日期 |
2015.10.27 |
申请号 |
US201214344644 |
申请日期 |
2012.09.14 |
申请人 |
Alkem Laboratories Limited |
发明人 |
Saralaya Sanjay Sukumar;Kunjyannaya Akshaya;Shashiprabha ;Kanakamajalu Shridhara;Rao Kothapalli Sundarraja;Nagarajan Kuppuswamy |
分类号 |
C07D317/36;C07D317/40 |
主分类号 |
C07D317/36 |
代理机构 |
|
代理人 |
Moxon, II George W.;Harrod Brian |
主权项 |
1. A compound of formula (I), |
地址 |
Mumbai IN |