| 摘要 |
FIELD: biotechnology.SUBSTANCE: invention relates to the field of biotechnology, specifically to production of version of alpha-1-antitrypsin, and can be used in medicine for prevention or treatment of deficiency of alpha-1-antitrypsin. The version of alpha-1-antitrypsin is obtained by replacement of amino acid in 4, 9 or 12 position of N-terminus of alpha-1-antitrypsin on asparagine for the purpose of adding the glycosylation site.EFFECT: invention enables to increase the period of half-life of alpha-1-antitrypsin in the body.8 cl, 10 dwg, 3 tbl, 5 ex |
