| 发明名称 | Post-synthetic modification of nucleic acids by inverse diels-alder reaction | ||
| 摘要 | The present invention concerns a method and a kit for the post-synthetic modification of nucleic acids via an inverse Diels-Alder reaction. | ||
| 申请公布号 | US9169283(B2) | 申请公布日期 | 2015.10.27 |
| 申请号 | US201213557698 | 申请日期 | 2012.07.25 |
| 申请人 | DEUTSCHES KREBSFORSCHUNGSZENTRUM;RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG | 发明人 | Wiessler Manfred;Lorenz Peter;Fleischhacker Heinz;Kliem Christian;Jäschke Andres;Schoch Juliane |
| 分类号 | C07H21/04;C07H21/00;C07H1/00 | 主分类号 | C07H21/04 |
| 代理机构 | Perkins Coie LLP | 代理人 | Perkins Coie LLP ;Kung Viola T. |
| 主权项 | 1. A method for the post-synthetic modification of nucleic acids, comprising the following steps: (a) preparing trans-cyclooctene-modified oligonucleotides, (b) preparing modified tetrazines, and (c) reacting the trans-cyclooctene-modified oligonucleotides with the modified tetrazines via inverse Diels Alder reaction. | ||
| 地址 | Heidelberg DE | ||