| 摘要 |
The present invention relates to derivatives of α,α-disubstituted amide compounds which comprise a substituted aryl at the α carbon such that the substituent provides a means for attachment or incorporation of the compound to or in a polymer. The provision of such a substituent on the aryl has surprisingly been found not only to permit attachment to or incorporation in a polymer but also retention of useful antifouling activity. In embodiments, the substituent is selected from hydroxyl, ethers, esters, carboxyls, alkylsilyls and alkenyls. Experiments demonstrate that antifouling activity can be as good or better as the corresponding unsubstituted compound and that polymers functionalized so as to include or be formed from the substituted compound can be used to reduce settlement. |
| 主权项 |
1. A compound of formula (I′) or a salt thereof: wherein R2 is wherein each of RA1, RA2, RA3, RA4 and RA5 is independently selected from OH, RS1OH, ORS2, RS1ORS2, OC(O)H, OC(O)RS2, RS1OC(O)H, RS1OC(O)RS2, C(O)OH, C(O)ORS2, RS1C(O)OH, RS1C(O)ORS2, ORS1OH, ORS1ORS2, ORS1OC(O)H, ORS1OC(O)RS2, ORS1C(O)OH, ORS1C(O)ORS2, H and RS2,
wherein, if present, each Rs1 is independently optionally substituted C1 to C5 alkylene, andwherein, if present, each RS2 is independently selected from optionally substituted C1 to C5 alkyl, C2 to C5 alkenyl and C1 to C5 alkylsilyl-C1 to C5 alkylene, with the proviso that at least one of RA1, RA2, RA3, RA4 and RA5 is not H or RS2, and R1 is selected from an unsubstituted saturated C3 to C5 alkyl and an unsubstituted C3 to C10 alkenyl; and R3 and R4 together with the nitrogen atom to which they are attached form an optionally substituted 6-membered heterocycle having the structure: wherein R5 and R6 are independently selected from hydroxyl, optionally substituted C1 to C6 alkyl, optionally substituted phenyl and H. |
