主权项 |
1. A heterofunctional polyoxazoline derivative of the general structure:
R1—{[N(COX)CH2CH2]o—[N(COR2)CH2—CH2)]n—[N(COY)CH2—CH2)]m}a—Zwherein:
R1 is an initiating group; R2 is independently selected for each repeating unit from an unsubstituted or substituted alkyl, an unsubstituted or substituted alkenyl, an unsubstituted or substituted aralkyl or an unsubstituted or substituted heterocyclylalkyl group; X is a pendent moiety containing a first functional group; Y is a pendent moiety containing a second functional group; Z is a terminating nucleophile, wherein Z is is S—U—W, wherein U is a linking group and W is a third functional group selected from the group consisting of: an alkyne, an amine, an oxyamine, an aldehyde, a ketone, an acetal, a ketal, an ester, a carboxylic acid, an activated carboxylic acid, an active carbonate, a chloroformate, an alcohol, an azide, a vinyl sulfone, a maleimide or orthopyridyl disulfide; a is ran which indicates a random copolymer or block which indicates a block copolymer; o and m are each an integer independently selected from 1-50; n is an integer selected from 0-1000; and wherein the first and second functional groups are chemically orthogonal to one another. |