| 主权项 |
1. A compound of Formula (I) or a salt thereof, wherein: HET is a heteroaryl selected from pyrazolyl, indolyl, pyrrolo[2,3-b]pyridinyl, pyrrolo[2,3-d]pyrimidinyl, pyrazolo[3,4-b]pyridinyl, pyrazolo[3,4-d]pyrimidinyl, 2,3-dihydro-1H-pyrrolo[2,3-b]pyridinyl, imidazo[4,5-b]pyridinyl, and purinyl, wherein said heteroaryl is substituted with Ra and Rb; Ra is H, F, Cl, Br, —CN, —OH, C1-4 alkyl, C1-4 fluoroalkyl, C1-4 hydroxyalkyl, C1-4 alkoxy, —NH2, —NH(C1-4 alkyl), —N(C1-4 alkyl)2, —NH(C1-4 hydroxyalkyl), —NH(C1-4 fluoroalkyl), —NH(C1-6 hydroxy-fluoroalkyl), —C(O)NH2, —CH2NHC(O)(C1-6 alkyl), —CH2NHC(O)(C1-6 hydroxyalkyl), —CH2NHC(O)NH(C1-6 alkyl), —CH2NHC(O)NHCH2(phenyl), —CH2NHC(O)N(C1-4 alkyl)2, —CH2NHC(O)O(C1-4 alkyl), —CH2NHC(O)(C3-6 cycloalkyl), —CH2NHC(O)(tetrahydrofuranyl), —CH2NHC(O)CH2(C3-6 cycloalkyl), —CH2NHC(O)CH2(tetrahydropyranyl), —CH2NHC(O)CH2(phenyl), —NHC(O)(C1-4 alkyl), pyrrolidinyl, hydroxypyrrolidinyl, or pyridazinyl; Rb is H or —NH2; R1 is:
(i) C1-6 alkyl, C1-6 fluoroalkyl, C1-6 hydroxyalkyl, C1-8 hydroxy-fluoroalkyl, —(C1-6 alkylenyl)O(C1-4 alkyl), —(C1-6 alkylenyl)O(C1-4 fluoroalkyl), —(C1-6 fluoroalkylenyl)O(C1-4 alkyl), —(C1-6 fluoroalkylenyl)O(C1-4 deuteroalkyl), —(C1-6 fluoroalkylenyl)O(C1-4 fluoroalkyl), —(C1-4 fluoroalkylenyl)C(C3-6 cycloalkyl)2(OH), —(C1-4 alkylenyl)NHC(O)(C1-4 alkylenyl)OC(O)(C1-3 alkyl), —(C1-6 alkylenyl)NHS(O)2(C1-4 alkyl), —(C1-6 alkylenyl)P(O)(C1-4 alkoxy)2, —(C1-6 fluoroalkylenyl)NH(C1-4 alkyl), —(C1-6 alkylenyl)C(O)NH(C1-4 alkyl), —(C1-6 fluoroalkylenyl)C(O)NH(C1-4 alkyl), —(C1-6 fluoroalkylenyl)C(O)NH(C1-4 hydroxyalkyl), or —(C1-6 fluoroalkylenyl)OP(O)(OH)2;(ii) —(C1-3 alkylenyl)Rx, —(C1-3 fluoroalkylenyl)Rx, —(C1-3 alkylenyl)C(O)Rx, —(C1-3 alkylenyl)C(O)NHRx, —(C1-3 fluoroalkylenyl)C(O)Rx, or —CH2CF=(tetrahydropyranyl), wherein Rx is a cyclic group selected from C3-6 cycloalkyl, tetrazolyl, 1,1-dioxidotetrahydrothiophenyl, 1,1-dioxidothiomorpholinyl, oxadiazolyl, piperidinyl, piperazinyl, pyrrolidinyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyridinyl, imidazolyl, morpholinyl, phenyl, and triazinyl, wherein each cyclic group is substituted with zero to 3 substituents independently selected from F, —OH, —CH3, —C(CH2)2OH, —OCH3, —C(O)CH2CN, —S(O)2CH3, —S(O)2NH2, —NHC(O)CH3, —N(S(O)2CH3)2, —CH2CH2(acetamidophenyl), —CH2CH2(methoxyphenyl), —CH2CH2(sulfamoylphenyl), oxetanyl, benzyl, and morpholinyl;(iii) C3-6 cycloalkyl or C4-6 cycloalkenyl, each substituted with zero to 3 substituents independently selected from F, —OH, —CN, C1-3 alkyl, C1-3 alkoxy, —S(C1-3 alkyl), —NO2, —S(O)2(C1-3 alkyl), C1-4 hydroxyalkyl, —C(C1-3 alkyl)(OH)(C3-6 cycloalkyl), —CH2C(O)NH(C1-3 alkyl), —NHC(O)(C1-3 alkyl), —NHC(O)(C1-4 hydroxyalkyl), —C(O)NH(C1-3 alkyl), —C(O)NH(C1-3 deuteroalkyl), —C(O)NH(C3-6 cycloalkyl), —NHC(O)O(C1-3 alkyl), —NHS(O)2(C1-3 alkyl), pyridinyl, imidazolyl, pyrazolyl, methylimidazolyl, methylpyrazolyl, and thiazolyl;(iv) tetrahydropyranyl, piperidinyl, pyrazolyl, phenyl, pyridinyl, or pyrimidinyl, each substituted with zero to 1 substituent selected from —OH, C1-3 alkyl, C1-3 fluoroalkyl, C1-4 hydroxyalkyl, C1-3 alkoxy, —C(O)(C1-4 alkyl), —S(O)2(C1-4 alkyl), —S(O)2NH(C1-4 alkyl), —NH(C1-3 alkyl), —N(C1-3 alkyl)2, —O(C1-3 alkylenyl)N(C1-3 alkyl)2, —CH2(morpholinyl), azetidinyl, oxetanyl, tetrahydropyranyl, morpholinyl, piperazinyl, piperidinyl, methylpiperazinyl, methoxypiperidinyl, pyridinyl, pyrimidinyl, methylsulfonyl azetidinyl, and —C(O)(methylsulfonyl azetidinyl); or(v) pyrrolo[2,3-c]pyridinyl, bicyclo[2.2.1]heptan-1-ol, tetrahydrobenzo[d]thiazol-2-amine, or 1,3-diazaspiro[4.5]decane-2,4-dione; and R2 is:
(i) C1-7 alkyl or C2-6 alkenyl, each substituted with zero to three substituents independently selected from F, —OH, and —CN; —(C1-4 alkylenyl)O(C1-4 alkyl), —(C1-4 alkylenyl)O(C1-4 fluoroalkyl), —(C1-6 alkylenyl)NH2, —(C1-6 alkylenyl)S(O)2(C1-3 alkyl), —(C1-6 fluoroalkylenyl)NH(C1-3 alkyl), or —(C1-6 alkylenyl)NHC(O)(C1-4 fluoroalkyl);(ii) —(C1-4 alkylenyl)Ry wherein Ry is C3-6 cycloalkyl, azetidinyl, oxetanyl, oxazolyl, pyridinyl, tetrahydropyranyl, or morpholinyl, each substituted with zero to 2 substituents independently selected from F, —OH, and C1-3 alkyl;(iii) C3-6 cycloalkyl, azetidinyl, oxetanyl, furanyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, or tetrahydropyranyl, each substituted with zero to 3 substituents independently selected from F, —OH, C1-3 alkyl, C1-3 hydroxyalkyl, —C(O)(C1-3 alkyl), —C(O)(C1-3 fluoroalkyl), —C(O)(C1-3 cyanoalkyl), —C(O)O(C1-3 alkyl), —C(O)NH2, —C(O)NH(C1-3 alkyl), —C(O)(difluorophenyl), —NH2, —NH(C1-3 alkyl), —NH(C1-3 fluoroalkyl), —NH(oxetanyl), —NHC(O)(C1-3 alkyl), —NHC(O)(C1-3 fluoroalkyl), —NHC(O)(C3-6 cycloalkyl), —NHC(O)(fluorophenyl), —S(O)2(C1-3 alkyl), imidazolyl, phenyl, pyrimidinyl, fluoropyrimidinyl, chloropyrimidinyl, and methoxypyrimidinyl;(iv) adamantanyl, hydroxyadamantanyl, benzo[d]imidazolyl, benzo[d]oxazolyl, benzo[d]triazolyl, benzothiazolyl, bicyclo[1.1.1]pentanyl, or hydroxy-bicyclo[2.2.1]heptanyl; or(v) phenyl, pyrazolyl, thiazolyl, thiadiazolyl, or indazolyl, each substituted with 0 to 2 substituents independently selected from F, Cl, —OH, —CN, C1-4 alkyl, C1-4 hydroxyalkyl, C1-4 fluoroalkyl, C1-4 cyanoalkyl, C1-3 alkoxy, C3-6 cycloalkyl, —(C1-3 alkylenyl)O(C1-3 alkyl), —(C1-3 alkylenyl)O(C1-3 fluoroalkyl), —C(O)NH2, —C(O)NH(C1-3 alkyl), —NHC(O)(C1-3 alkyl), —NHC(O)S(O)2(C1-3 alkyl), —S(O)2NH2, —S(O)2(C1-3 alkyl), pyrazolyl, methyl pyrazolyl, imidazolyl, triazolyl, methyl tetrazolyl, ethyl tetrazolyl, phenyl, pyrimidinyl, fluoropyrimidinyl, and tetrahydropyranyl. |
