Glycerophospholipids for the improvement of cognitive functions

摘要

The invention described herein provides a preparation comprising a non-mammalian derived mixture of serine glycerophospholipid conjugates with a specific content and specific conjugation patterns of LA, linolenic acid (alpha-linolenic acid, gamma-linolenic acid) DHA and EPA which depend on utilizing different sources of lipids, and uses of such preparations.

主权项

1. A method of improving a condition in an elderly subject with a disorder involving impaired cognitive performance which comprises administering to the subject an effective amount of a preparation comprising a non-mammalian derived mixture of serine glycerophospholipid conjugates, wherein the mixture comprises (a) linoleic acid (C18:2) conjugated to phosphatidylserine (PS), (b) docosahexaenoic acid (DHA) conjugated to PS, and (f) eicosapentaenoic acid (EPA) conjugated to PS, in which mixture the w/w % of (a)/the w/w % of (b) is from about 0.09 to about 3.6 and the w/w % of (a)/w/w % of (f) is from about 0.23 to about 9.4, and wherein the disorder is selected from the group consisting of cognitive impairment no dementia, pre-Alzheimer's disease, pre-dementia syndrome, age related cognitive decline, cognitive deterioration and any combination of two or more of such disorders.