| 发明名称 | Process for preparing pharmaceutical compounds and intermediate compounds | ||
| 摘要 | The object of the present invention is a process for preparing the 2-acetoxi-5-(2-fluor-α-cyclopropyl-carbonyl-benzyl)-4,5,6,7-tetrahydro-4H-thieno[3,2-c]pyridine (prasugrel) of the formula (I). The process starts from crystalline 5-trityl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine of the formula (VI).;Further objects of the present invention are two novel crystalline forms of 5-trityl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine of the formula (VI) and the use thereof for preparing the compound of the formula (V) and process preparing thereof. | ||
| 申请公布号 | US9169265(B2) | 申请公布日期 | 2015.10.27 |
| 申请号 | US201013517397 | 申请日期 | 2010.12.21 |
| 申请人 | EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG | 发明人 | Porcs-Makkay Márta;Volk Balázs;Gregor Tamás;Barkóczy József;Mezei Tibor;Broda Judit;Nyulasi Bálint;Ruzsics György;Molnár Enikö;Debreczeni József;Nagy Kálmán;Pandur Angéla;Szent-Királlyi Zsuzsanna |
| 分类号 | C07D495/04 | 主分类号 | C07D495/04 |
| 代理机构 | Birch, Stewart, Kolasch & Birch, LLP | 代理人 | Birch, Stewart, Kolasch & Birch, LLP |
| 主权项 | 1. Form I of 5-trityl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine of the formula (VI) which shows an X-ray powder diffraction pattern having characteristic peaks at reflection angle 2Θ(±0.2° 2Θ) of about 10,236; 11,938; 17,929; 19,527; 24,427. | ||
| 地址 | Budapest HU | ||