| 发明名称 | Conserved Neisserial antigens | ||
| 摘要 | To ensure maximum cross-strain recognition and reactivity, regions of proteins that are conserved between different Neisserial species, serogroups and strains can be used. The invention provides proteins which comprise stretches of amino acid sequence that are shared across the majority of Neisseria, particularly N. meningitidis and N. gonorrhoeae. | ||
| 申请公布号 | US9169301(B2) | 申请公布日期 | 2015.10.27 |
| 申请号 | US200912589218 | 申请日期 | 2009.10.19 |
| 申请人 | GlaxoSmithKline Biologicals SA | 发明人 | Rappuoli Rino |
| 分类号 | A61K39/095;C07K14/22;A61K39/00 | 主分类号 | A61K39/095 |
| 代理机构 | Morrison & Foerster LLP | 代理人 | Morrison & Foerster LLP |
| 主权项 | 1. An immunogenic composition comprising a pharmaceutically acceptable excipient, an adjuvant, and an isolated polypeptide comprising a fragment conserved in SEQ ID NOs: 119-124, wherein the fragment conserved in SEQ ID NOs: 119-124 includes at least 10 or more contiguous amino acids in any of SEQ ID NOs: 222, 223, 226, 227, 228, 229, 230, and 231, provided that said polypeptide does not comprise a full-length Neisserial protein selected from SEQ ID NOs: 119-124. | ||
| 地址 | Rixensart BG | ||