ADENOVIRAL BASED BIOLOGICAL DELIVERY AND EXPRESSION SYSTEM FOR USE IN THE TREATMENT OF OSTEOARTHRITIS

摘要

The invention relates to an adenoviral based biological delivery and expression system for use in the treatment or prevention of osteoathritis in human or mammalian joints by long term inducible gene expression of human or mammalian interleukin 1 receptor antagonist (II 1 Ra) in synovial cells comprising a helper dependent adenoviral vector containing a nucleic acid sequence encoding for human or mammalian interleukin 1 receptor antagonist (II 1 Ra) left and right inverted terminal repeats (L ITR and R ITR) the adenoviral packaging signal and non viral non coding stuffer nucleic acid sequences wherein the expression of the human or mammalian interleukin 1 receptor antagonist (II 1 Ra) gene within synovial cells is regulated by an inflammation inducible promoter.