| 摘要 |
Subpopulations of spore-like cells expressing specific surface and gene expression mzkers are provided. In one embodiment, the cells express at least one cell surface or gene expression marker selected from the group consisting of Oct4, -0-296, cripto, Gdf3, UtFI, Ecatl, Esgl, Sox% Pax6, nestin, SCA-1, CD29, CD34, CD90, B1 integrin, cKit, SP-C, CC10, SFl, DAXl and SCG10. Also provided are methods for puriQimg a subpopulation of spore-like cells of interest hm a population of spore-like cells, and methods for inducing differentiation of the isolated spore-like cells into cells of endodermal, mesodermal 1 or ectodermal origin. The spore-like cells can be used to generate cells originating fi-om all three germ layers and can be used to I treat a patient who has a dsficiency of functional cells in any of a wide variety of tissues, including the retina, intestine, bladder, 1 kidney, liver, lung, nervous system, or endocrine system. i |
