PREPARATION OF NEW INTERMEDIATE OF HEPARIN PENTASACCHARIDE AND PREPARATION METHOD THEREOF

摘要

The present invention relates to a process of a chemically synthetic drug, and in particular, to a new intermediate of a heparin pentasaccharide and a preparation method thereof. The process has high reaction efficiency, and an easy reaction operation. The reaction intermediate is easy to be purified, and is appropriate for an industrialization production.

主权项

1. A compound having the following formula I, which can be used as an intermediate for the preparation of heparin pentasaccharide, wherein the configuration of monosaccharide units and the stereochemistry of the connecting bond among each of the monosaccharides is D-glucosyl-α-1,4-D-glucuronosyl-β-1,4-D-glucosyl-α-1,4-L-idoronosyl-α-1,4-D-glucose, wherein the definition of each substituent is as follows: R represents C1-C20 alkyl or substituted alkyl, wherein the alkyl can be either linear alkyl or branched or cyclic alkyl; R4 represents benzyl or substituted benzyl, and R4 in the same molecular formula represents either identical group or different group; R5 represents hydrogen ion or alkali metal ion.