IMPLANTABLE BIOARTIFICIAL PERFUSION SYSTEM

摘要

The disclosure provides an implantable bioartificial active secretion system for providing a physiological regulating secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing implantable within the host, in fluidic communication with tissue fluid indicative of a physiological regulating secretion need. A chamber within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological regulating secretion. A continually operating two pump apparatus moves tissue fluid into contact with the secretory cells for pick up of the physiological regulating secretion for subsequent physiologically-effective dispensing into the host, while avoiding immuno-rejection of the host body or of the host to the secretory cells.

主权项

1. An implantable bioartificial perfusion system for providing a physiological regulating secretion necessary for functionality of a physiologic activity of a living-being host, the system comprising:
a) a housing having an inlet with an external opening thereto and an outlet with an external opening therefrom, the housing implantable at least partially within the host such that the inlet and outlet openings are positionable in fluidic communication with tissue fluid of the host for receiving into and dispensing from the housing the tissue fluid; b) a chamber disposed within the housing between the inlet and outlet and m communication therewith, the chamber having therein a plurality of physiologically active, autonomously and in concert functioning, live secretory cells for producing the physiological regulating secretion; c) a constantly operating two pump apparatus for drawing initial tissue fluid through the inlet from the host for contact with the physiologically active cells within the chamber for pick up of the physiological regulating secretion, and for dispensing resulting tissue fluid bearing the physiological regulating secretion through the outlet and into the host; and d) an inlet filter in operational communication with the external opening of the inlet and disposed upstream of the chamber, wherein the inlet filter comprises a plurality of mesh woven polymer yarn to collect peritoneal fluid from a high surface area of the parietal peritoneum and visceral peritoneum by means of capillary forces and a size-exclusion membrane filter separated from the plurality of mesh woven polymer yarn by a capillary gap for prohibiting passage into the chamber of immune system cells of the host.