| 摘要 |
The inhibitory oligonucleotides (ODNs) which strongly block NF-κB activation induced by TLR9 agonists and TLR7 agonists are provided. The production of proinflammatory cytokines, such as interleukin-6 and tumor necrosis factor alpha, is inhibited by the inhibitory-ODNs. Interferon production from human PBMC induced by TLR9 agonist is prevented by the inhibitory-ODNs. These ODNs can be used as a remedy for the treatment of immune-mediated disorders such as rheumatoid arthritis, systemic lupus erythematosus (SLE), sepsis, multiple organ dysfunction syndromes. |
| 主权项 |
1. An oligonucleotide comprises a sequence that is selected from the group consisting of(SEQ ID NO: 1)5′-cctcctcctcctcctcctcctcctc-3′,(SEQ ID NO: 2)5′-cctcctcctcctcctcctcctcctcc-3′,(SEQ ID NO: 3)5′-cctcctcctcctcctcctcctcctcct-3′,(SEQ ID NO: 4)5′-cctcctcctcctcctcctcctcctcctc-3′,(SEQ ID NO: 5)5′-cctcctcctcctcctcctcctcctcctcc-3′,(SEQ ID NO: 6)5′-cctcctcctcctcctcctcctcctcctcct-3′,(SEQ ID NO: 7)5′-cctcctcctcctcctcctcctcctcctcctc-3′,(SEQ ID NO: 8)5′-cctcctcctcctcctcctcctcctcctcctcc-3′,(SEQ ID NO: 9)5′-cctcctcctcctcctcctcctcctcctcctcct-3′,(SEQ ID NO: 10)5′-cctcctcctcctcctcctcctcctcctcctcctc-3′,(SEQ ID NO: 11)5′-cctcctcctcctcctcctcctcctcctcctcctcc-3′,(SEQ ID NO: 12)5′-cctcctcctcctcctcctcctcctcctcctcctcct-3′,(SEQ ID NO: 13)5′-cctcctcctcctcctcctcctcctcctcctcctcctcctcct-3′,(SEQ ID NO: 14)5′-cctcctcctcctcctcctcctcctcctcctcctcctcctcctcctcct-3′,(SEQ ID NO: 15)5′-cctcctcctcctcctcct-3′,and(SEQ ID NO: 16)5′-cctcctcctcctcctcctcct-3′. |
