ASGPR ANTIBODIES AND USES THEREOF

摘要

The present invention generally relates to antibodies specific for asialoglycoprotein receptor (ASGPR) and their use for selectively delivering effector moieties that influence cellular activity. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies of the invention, and to methods of using them in the treatment of disease.

主权项

1. An antibody for specific binding to asialoglycoprotein receptor (ASGPR), wherein the antibody comprises
a) a heavy chain variable region sequence of SEQ ID NO: 16 and a light chain variable region sequence of SEQ ID NO: 14; b) a heavy chain variable region sequence of SEQ ID NO: 4 and a light chain variable region sequence of SEQ ID NO: 2; c) a heavy chain variable region sequence of SEQ ID NO: 8 and a light chain variable region sequence of SEQ ID NO: 6; d) a heavy chain variable region sequence of SEQ ID NO: 12 and a light chain variable region sequence of SEQ ID NO: 10; e) a heavy chain variable region sequence of SEQ ID NO: 20 and a light chain variable region sequence of SEQ ID NO: 18; f) a heavy chain variable region sequence of SEQ ID NO: 24 and a light chain variable region sequence of SEQ ID NO: 22; g) a heavy chain variable region sequence of SEQ ID NO: 28 and a light chain variable region sequence of SEQ ID NO: 26; h) a heavy chain variable region sequence of SEQ ID NO: 4 and a light chain variable region sequence of SEQ ID NO: 30; i) a heavy chain variable region sequence of SEQ ID NO: 4 and a light chain variable region sequence of SEQ ID NO: 32; j) a heavy chain variable region sequence of SEQ ID NO: 4 and a light chain variable region sequence of SEQ ID NO: 34; or k) a heavy chain variable region sequence of SEQ ID NO: 24 and a light chain variable region sequence of SEQ ID NO: 22.